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Conventionally, studies have focused on the role of aberrant splicing of single genes in cancer. High-throughput functional genomics approaches can be harnessed to systematically explore additive and synergistic effects of aberrant splicing modules in promoting carcinogenesis and resistance to therapies. Specifically, a identify effects of recurrent intronic and synonymous mutations on splicing of tumor drivers; b explore the role of mutated and dysregulated splicing factors such as SF3B1 in bladder tumorigenesis; and c recreate systematically tumor-specific splicing dependencies and evaluate them for therapeutic purposes using nucleic acid-based strategies like antisense or splice switching oligos SSOs.
Biography Dr. His thesis focused on how alternative promoter usage and mRNA splicing spatiotemporally regulate protein kinase A complex subunit genes. During his Ph. Banday received a European Science Foundation summer school fellowship for training in bioinformatics at the University of Nottingham, United Kingdom As a postdoctoral fellow at the University of Connecticut, from , he studied gene regulation in mouse retinal development.
He used computational and functional genomics approaches in studying cancer-associated genetic loci and mutational processes focusing on bladder cancer. These deaminase enzymes cause genomic mutations and drive tumor evolution. The temple is dedicated to goddess Angleshwari Vindhyavasini.
There are many murtis of Devis and Devatas in the temple. Nawab Tank[ edit ] Nawab tank, which was built to fulfill the water needs in Banda, is situated about 3 km south of Banda. This tank was built by the Nawab of Banda, and therefore it is known as the Nawab Tank. George's Church Yellow Church [ edit ] St. George's Church Yellow Church St.
Some records have been found that proved that Christianity was in Banda before AD. The Church is dedicated to the British patron saint George the Martyr. The Church has many historic memorials of British officers in Banda. There is a grave of British officers inside the church. Outside the Church, there are three graves of British officers from the Royal Army and the grave of the first Chaplain of the church.
During revolt, no damage was made to the Church.